Gene Regulatory Networks

Bacillus subtilis

  • Model organism for pathogens
    • Bacillus anthracis
    • Staphylococcus aureus
  • Lots of data
\[ \begin{array}{c|ccc} & TF1 & TF2 & \sigma \\ \hline TF1 & 0 & -1 & -1 \\ TF2 & 0 & 0 & 1 \\ \sigma & 0 & 1 & 0\end{array} \]

Objectives of the Paper

  • "Infer" a transcriptional regulatory network
  • Evaluate the model with experimental data
Novel Regulatory Interactions Recall of Prior Interactions Accuracy
2,258 74% 62%

What is the point?

  • First global network for Bacillus subtilis
  • Regulatory networks drive discovery of new interactions
  • Understanding B. subtilis facilitates treatment generation for pathogens