PU.1 is a Transcription Factor that activates genes during immune cell development. It is coded for by the SPI1 gene.
Details
- 272 Amino Acids
- transcriptional activation domain in N-terminal 100 amino acids
- DNA binding domain in C-terminal 112 amino acids
- required for most myeloid lineages and B cells
- Implicated in cytokines
Useful Resources
[Transcription factor PU.1 is a critical regulator of cellular communications in the immune system](PU-1.pdf)❌
[Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development](PU-1-mechanism.pdf)❌ https://pubmed.ncbi.nlm.nih.gov/37492098/
GWAS Paper
[Blood cell traits’ GWAS loci colocalization with variation in PU.1 genomic occupancy prioritizes causal noncoding regulatory variants](PU-1GWAS.pdf)❌
- It is hard to identify casual variants in Genome Wide Association Studies (GWAS).
- Identification of the casual variants is useful for genetic risk predictions
-
effective method to capture genetic effects is TF
[[bQTLs.md]]❌