gene expression and disease

• Disease = cell making a bad descision

transcriptional regulationm

• large scale interactions between genes that are very far away in one-dimensional space

Day 2

public domain data

• lots of data exists

• reanalysis of existing data is useful

bulk vs single cell

• each cell has a unique gene signature

Pop quiz

• Expression meausreuments have a stochastic component
• average behavior (separate signal from noise)
• Statistical model defines probability of an outcome
• statistical models explicitly separates signal (average behavior) from noise