• Harley et al identifies PU.1 as important regulator
• PU1 in LUPUS

Act 1

Systematic ChIP-seq datasets for PU.1 in different cell types

Act 2

Mechanism: potential differential binding of PU.1 in cell type specific way

Act 3

Revisit RELI (disease against differential binding?)

Mario

Todo list

Phenotype RELI

• GWAS catalogue contains unecessary factors (non-diseases)
• Leah wants to remove these factors
• GWAS contains many logical ORs that don't make sense (disease 1 OR disease 2)
• GM12878 vs NA12878 is the same

RELI

• All cell types
• each cell types
• cell type specific?

Only need to run if 10 or more risk loci are identified.

Figure 4 of harley paper.

MARIO Results

Bulyk's LCLs

• MARIO analysis on these

Xioting

Masked human genome?